Preanalytical Stability of CSF Total and Oligomeric Alpha-Synuclein
نویسندگان
چکیده
منابع مشابه
Abnormal Salivary Total and Oligomeric Alpha-Synuclein in Parkinson's Disease.
In Parkinson's disease (PD), alpha-synuclein (a-syn) can be detected in biological fluids including saliva. Although previous studies found reduced a-syn total (a-syntotal) concentration in saliva of PD patients, no studies have previously examined salivary a-syn oligomers (a-synolig) concentrations or assessed the correlation between salivary a-syntotal, a-synolig and clinical features in a la...
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This data article presents a dataset of total, oligomeric alpha-synuclein and hemoglobin levels in plasma of drug-naïve PD patients and controls. This is the first attempt to assess the effect of hemolysis rate on oligomeric alpha-synuclein levels in peripheral plasma. The data are associated with the research article "Oligomeric alpha-synuclein and glucocerebrosidase activity levels in GBA-ass...
متن کاملSalivary total α-synuclein, oligomeric α-synuclein and SNCA variants in Parkinson’s disease patients
The present study was to evaluate the diagnostic value of salivary total and oligomeric α-synuclein levels in PD. Furthermore, we sought to explore the relationship between salivary total α-synuclein and α-synuclein SNP variants levels. 201 PD patients and 67 controls were recruited, of which there also had the genetic information of two positive α-synuclein (SNCA) loci. Salivary total α-synucl...
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Several studies reported an association between CSF alpha-synuclein (α-syn) and tau in Alzheimer's disease (AD), and demonstrated the significance of α-syn in improving the diagnostic sensitivity/specificity of classical AD CSF biomarkers. In the current study, we measured CSF levels of different α-syn species in a cohort of AD patients (n = 225) who showed a CSF profile typical of AD at baseli...
متن کاملBRIEF COMMUNICATION Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies
Alpha-synuclein RT-QuIC in the CSF of patients with alpha-synucleinopathies Graham Fairfoul, Lynne I. McGuire, Suvankar Pal, James W. Ironside, Juliane Neumann, Sharon Christie, Catherine Joachim, Margaret Esiri, Samuel G. Evetts, Michal Rolinski, Fahd Baig, Claudio Ruffmann, Richard Wade-Martins, Michele T. M. Hu, Laura Parkkinen & Alison J. E. Green The National CJD Research & Surveillance Un...
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ژورنال
عنوان ژورنال: Frontiers in Aging Neuroscience
سال: 2021
ISSN: 1663-4365
DOI: 10.3389/fnagi.2021.638718